Predictors, Moderators, & Mediators Associated w/ Treatment Outcome Among Adolescents w/ Depression

Predictors, Moderators, and Mediators Associated With Treatment Outcome in Randomized Clinical Trials Among Adolescents With Depression, in JAMA Network Open

Key takeaway: "In this scoping review of 33 RCTs with results described across 81 publications, variable domains reported as significant in at least 3 RCTs with respect to depression outcomes included age, sex/gender, baseline depression severity, early response to treatment, sleep changes, parent-child conflict, overall psychopathology, suicidal ideation, hopelessness, functional impairment, attendance at psychotherapy sessions, and history of trauma. A small minority of publications reported efforts to minimize bias through a priori hypothesis testing and adjustment for multiple comparisons."