Age-Adjusted Drug Overdose Death Rates by State — National Vital Statistics System, United States, 2021, in Morbidity and Mortality Weekly Report
key takeaway: "In 2021, the U.S. age-adjusted drug overdose death rate was 32.4 per 100,000 population. The highest rates were in West Virginia (90.0) and the District of Columbia (63.6); the lowest rates were in the Upper Midwest and Texas. The lowest state rates were those in Nebraska (11.4), South Dakota (12.6), and Iowa (15.3)."
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